2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19589
    JTS-653 942614-99-5 98%
    JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents.
    JTS-653
  • HY-19623
    VU0092273 393110-43-5 98%
    VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM.
    VU0092273
  • HY-19648
    Ebiratide 105611-68-5 98%
    Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain.
    Ebiratide
  • HY-19665
    Lanepitant 170566-84-4 98%
    Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to NK-1 receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis.
    Lanepitant
  • HY-19818
    NAN-190 102392-05-2 98%
    NAN-190 is a serotonin receptor 5-HT antagonist.
    NAN-190
  • HY-19845
    Ordopidine 871351-60-9 98%
    Ordopidine is a dopamine D2 receptor antagonist. Ordopidine can inhibit hyperactivity caused by psychostimulants. Ordopidine can be used in neurological research.
    Ordopidine
  • HY-19857
    Sulcardine sulfate 343935-61-5 98%
    Sulcardine (sulfate) is a novel multi-ion channel blocker with activity against Na+, K+ and Ca2+ channels. Sulcardine has antiarrhythmic activity.
    Sulcardine sulfate
  • HY-19858
    LY-466195 317844-33-0 98%
    LY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC50 value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC50 values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively.
    LY-466195
  • HY-19875
    Seridopidine 883631-51-4 98%
    Seridopidine is an orally active dopamine-like compound. Seridopidine can be used in research related to the nervous system.
    Seridopidine
  • HY-19881
    ABT-288 948845-91-8 98%
    ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has Ki values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research..
    ABT-288
  • HY-19887
    Tilapertin 1000690-85-6 98%
    Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
    Tilapertin
  • HY-19902
    GSK1521498 1426543-84-1 98%
    GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents.
    GSK1521498
  • HY-19950
    5-HT2A receptor agonist-6 1028307-48-3 98%
    5-HT2A receptor agonist-6 (compound 47) is a selective 5-HT2A receptor agonist (pEC50=6.58).
    5-HT2A receptor agonist-6
  • HY-19999
    PF-CBP1 1962928-21-7 98%
    PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain.
    PF-CBP1
  • HY-21994
    Org-12962 hydrochloride 210821-63-9 98%
    Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.
    Org-12962 hydrochloride
  • HY-21995
    BGC20-761 17375-63-2 98%
    BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent.
    BGC20-761
  • HY-32854
    4-Bromo-3-(trifluoromethyl)aniline 393-36-2 99.52%
    4-Bromo-3-(trifluoromethyl)aniline (5-Amino-2-bromobenzotrifluoride) can be used for synthesis of AUY954 (HY-119221) (a S1P1 receptor agonist).
    4-Bromo-3-(trifluoromethyl)aniline
  • HY-41240
    (R)-3-Aminoazepan-2-one 28957-33-7 98%
    (R)-3-Aminoazepan-2-one (compound 9B) is a synthetic intermediate useful for pharmaceutical synthesis.
    (R)-3-Aminoazepan-2-one
  • HY-42649
    NSC 14699 2513-33-9 99.64%
    NSC 14699 is a small molecule non-peptide inhibitor of botulinum neurotoxin serotype E. NSC 14699 is promising for research of therapeutic and cosmetic agents.
    NSC 14699
  • HY-42849
    Sultopride 53583-79-2 98%
    Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.
    Sultopride
Cat. No. Product Name / Synonyms Application Reactivity